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Correlation between quantitative parameters of CEUS and Ki-67 labeling index in soft-tissue sarcoma
Pingping Wang1, Di Xu2, Yu Hu2
1Department of Ultrasound, Affiliated Zhongda Hospital of Southeast University, Nanjing, PR China.
Acta Radiologica (Stockholm, Sweden : 1987)
|July 29, 2022
Summary
Contrast-enhanced ultrasound (CEUS) rise time (RT) can predict soft-tissue sarcoma (STS) proliferation. This non-invasive method correlates with Ki-67 labeling index (LI), offering a new tool for prognosis prediction.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Clinicians require non-invasive methods to predict soft-tissue sarcoma (STS) prognosis.
- Current methods rely on immunohistochemical Ki-67 labeling index (LI).
Purpose of the Study:
- To evaluate the correlation between quantitative contrast-enhanced ultrasound (CEUS) parameters and Ki-67 LI in STS.
- To determine if CEUS can serve as a non-invasive prognostic tool for STS.
Main Methods:
- 25 STS patients underwent CEUS using SonoVue®.
- Patients were stratified into high- and low-proliferation groups based on Ki-67 LI (≥30% vs. <30%).
- Quantitative CEUS parameters, including rise time (RT), were analyzed from time-intensity curves.
Main Results:
- CEUS RT was significantly higher in the high-proliferation STS group compared to the low-proliferation group (P=0.01).
- An optimal cutoff RT of 10.84s distinguished between groups with 86.7% sensitivity and 80% specificity.
- Area under the curve (AUC) for RT was 0.80.
Conclusions:
- CEUS RT demonstrates a significant correlation with Ki-67 LI in STS.
- CEUS RT can serve as a minimally invasive auxiliary tool for predicting STS prognosis.
- This technique offers a convenient alternative to invasive biopsies for prognostic assessment.
