Related Experiment Video

Updated: Sep 3, 2025

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
09:37

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Published on: September 23, 2022

2.0K

Safety and Acceptance of COVID-19 Vaccination After Multisystem Inflammatory Syndrome in Children (MIS-C) in Spain

Cristina Epalza1,2,3,4, Luis Prieto-Tato1,2,3,4, Rosa Pino5

  • 1Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario 12 de Octubre, Madrid, Spain.

Journal of the Pediatric Infectious Diseases Society
|July 29, 2022
PubMed

Insights

COVID-19 vaccination in adolescents with prior multisystem inflammatory syndrome (MIS-C) showed a low incidence of adverse events. Importantly, no new MIS-C or myocarditis cases were observed post-vaccination.

Area of Science:

  • Pediatric immunology
  • Vaccinology
  • Infectious disease epidemiology

Background:

  • Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition following SARS-CoV-2 infection.
  • Concerns exist regarding the safety and efficacy of COVID-19 vaccines in adolescents with a history of MIS-C.

Purpose of the Study:

  • To evaluate the safety and incidence of new MIS-C or myocarditis following COVID-19 vaccination in adolescents with a previous MIS-C diagnosis.

Main Methods:

  • A cohort study of 42 adolescents with a prior MIS-C diagnosis.
  • Tracking of vaccination status and adverse events post-COVID-19 vaccination.
  • Median follow-up of 10 weeks post-vaccination.

Main Results:

  • 76.2% (32 out of 42) of adolescents received COVID-19 vaccines.
  • A low incidence of relevant adverse events was reported.
  • No new cases of MIS-C or myocarditis were observed during the follow-up period.

Conclusions:

  • COVID-19 vaccination appears safe in adolescents with a history of MIS-C.
  • Vaccination did not lead to a recurrence or new onset of MIS-C or myocarditis in this cohort.

Keywords:
COVID-19acceptancemultisystem inflammatory syndrome in children (MIS-C)safetyvaccination

More Related Videos

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.5K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

15.9K

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
45.2K
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
14
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
25
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
974
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
20