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Related Experiment Video

Updated: Sep 3, 2025

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LONGITUDINAL ANALYSIS OF TRANSCRIPTOMIC SUBTYPES IN TRAUMA PATIENTS.

Tianmeng Chen, Yue Wei1, Yoram Vodovotz2

  • 1Department of Biostatistics, School of Public Health, University of Pittsburgh, Pennsylvania.

Shock (Augusta, Ga.)
|July 29, 2022
PubMed
Summary

Trauma patients

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Area of Science:

  • Trauma research
  • Immunology
  • Genomics

Background:

  • Two transcriptomic subtypes (Signature Groups: SG1 vs. SG2) were previously identified in trauma patients 12 hours post-injury.
  • SG1 subtype was associated with worse patient outcomes.

Purpose of the Study:

  • To characterize longitudinal changes in trauma patient transcriptomic subtypes (SG1/SG2) over time.
  • To define the association between subtype designation timing and patient outcomes.

Main Methods:

  • Secondary analysis of whole-blood leukocyte transcriptomic data from 167 severe blunt trauma patients.
  • Longitudinal assignment of patients to SG1 or SG2 subtypes from 12 hours to 28 days post-injury.
  • Characterization of longitudinal patient outcomes based on subtype.

Main Results:

  • SG1 subtype assignment consistently correlated with slower recovery, irrespective of the time point.
  • Assessing SG subtype at both 12 hours and 1 day provided additional prognostic information.
  • Immune status can deteriorate after hospital admission in trauma patients.

Conclusions:

  • Longitudinal monitoring of transcriptomic subtypes (SG) in trauma patients offers significant prognostic value.
  • Dynamic changes in immune status post-injury can be tracked using transcriptomic subtyping.
  • This approach provides a proof of concept for improved trauma outcome prediction.