Related Experiment Video
Updated: Sep 3, 2025
06:05
Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection
Published on: October 12, 2017
15.8K
Melanosis of the urinary bladder
H Ni Raghallaigh1, A Pineda-Turner1, K Mather1
1Frimley Health NHS Foundation Trust, UK.
Annals of the Royal College of Surgeons of England
|July 29, 2022
Summary
Melanosis bladder, a rare condition of melanin deposition in the urothelium, is poorly understood. This case highlights a potential association with voiding symptoms and hypospadias in a male patient.
Area of Science:
- Urology
- Pathology
- Medical Case Reports
Background:
- Melanosis bladder is characterized by black, velvety urothelium due to melanin deposition.
- Etiology, risk factors, and clinical significance remain largely unknown due to infrequent reporting.
- Existing literature includes sporadic cases with varied clinical presentations, including absence of symptoms or malignancy.
Observation:
- A case of melanosis bladder is presented in a male patient.
- The patient experienced voiding urinary symptoms.
- The patient had a history of untreated hypospadias.
Findings:
- Microscopic examination confirmed melanin deposition in the bladder urothelium.
- The co-occurrence of melanosis bladder with voiding symptoms and hypospadias is noted.
- This presentation adds to the limited case data on melanosis bladder.
Implications:
- Further research is needed to elucidate the pathogenesis and risk factors of melanosis bladder.
- Understanding potential associations may improve diagnosis and management of this rare condition.
- This case underscores the importance of thorough patient history and examination in evaluating urothelial abnormalities.
Related Concept Videos
01:23Urinary Bladder
1.4K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
1.4K
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
186
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
186
01:19Pigmentation
2.6K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.6K
01:14Changes in Skin Color: Clinical Perspectives
2.1K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.1K
01:30Skin Cancer
4.4K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.4K
01:26The Micturition Reflex
974
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
974