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Boosting Antitumor Immunity with an Expanded Neoepitope Landscape

Remco Nagel1, Abhijeet Pataskar1, Julien Champagne1

  • 1Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Cancer Research
|July 29, 2022
PubMed

Insights

Novel immunotherapy strategies are needed for cancers with low neoantigen loads. This review explores noncanonical neoepitopes to enhance cancer immunotherapy efficacy.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Immune-checkpoint blockade therapy is effective for cancers with high mutational burden and neoantigens.
  • Tumors with low neoantigen expression remain a challenge for current immunotherapies.

Purpose of the Study:

  • To review recent advances in neoantigen discovery.
  • To highlight novel classes of noncanonical neoepitopes for therapeutic development.

Main Methods:

  • Literature review of recent studies on neoantigen discovery.
  • Focus on non-genetically encoded and inducible neoepitopes.

Main Results:

  • Identification of novel classes of noncanonical neoepitopes.
  • Exploration of new therapeutic avenues to enhance immunotherapy sensitivity.

Conclusions:

  • Noncanonical neoepitopes offer promising strategies to overcome limitations of current cancer immunotherapies.
  • Further research into these neoepitopes can improve treatment outcomes for a broader range of cancer patients.

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