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Boosting Antitumor Immunity with an Expanded Neoepitope Landscape.
Remco Nagel1, Abhijeet Pataskar1, Julien Champagne1
1Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Cancer Research
|July 29, 2022
Summary
Novel immunotherapy strategies are needed for cancers with low neoantigen loads. This review explores noncanonical neoepitopes to enhance cancer immunotherapy efficacy.
Area of Science:
- Oncology
- Immunology
- Cancer Research
Background:
- Immune-checkpoint blockade therapy is effective for cancers with high mutational burden and neoantigens.
- Tumors with low neoantigen expression remain a challenge for current immunotherapies.
Purpose of the Study:
- To review recent advances in neoantigen discovery.
- To highlight novel classes of noncanonical neoepitopes for therapeutic development.
Main Methods:
- Literature review of recent studies on neoantigen discovery.
- Focus on non-genetically encoded and inducible neoepitopes.
Main Results:
- Identification of novel classes of noncanonical neoepitopes.
- Exploration of new therapeutic avenues to enhance immunotherapy sensitivity.
Conclusions:
- Noncanonical neoepitopes offer promising strategies to overcome limitations of current cancer immunotherapies.
- Further research into these neoepitopes can improve treatment outcomes for a broader range of cancer patients.
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