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Influence of Boron Neutron Capture Therapy on Normal Liver Tissue
Yuki Tamari1,2, Takushi Takata2, Satoshi Takeno2
1Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Radiation Research
|July 29, 2022
Summary
Boron neutron capture therapy can cause liver fibrosis and fat accumulation. Hedgehog signaling activation is linked to these adverse events, suggesting it may indicate therapy-related liver injury.
Area of Science:
- Hepatology
- Radiation Oncology
- Molecular Biology
Background:
- Radiation can induce liver damage, including fibrosis, a late-onset injury.
- Evaluating adverse liver events after boron neutron capture therapy (BNCT) requires understanding radiation's effects.
Purpose of the Study:
- To establish a method for analyzing liver fibrosis after BNCT.
- To investigate the role of hepatocellular fat accumulation and Sonic Hedgehog signaling in BNCT-induced liver injury.
Main Methods:
- Mice were injected with p-boronophenylalanine before neutron irradiation.
- Liver fibrosis was assessed using Masson trichrome staining.
- Fat accumulation was evaluated via H&E staining and triglyceride quantification.
- Sonic Hedgehog expression was measured using Western blotting.
Main Results:
- Neutron irradiation with p-boronophenylalanine significantly increased liver fat accumulation and fibrosis compared to controls.
- Sonic Hedgehog expression was elevated in response to BNCT-induced liver injury.
- Increased Sonic Hedgehog expression was correlated with liver fibrosis.
Conclusions:
- Hepatocellular fat accumulation and Hedgehog signaling activation are associated with BNCT-induced liver fibrosis.
- These factors may serve as indicators of adverse liver events following BNCT.
