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3D Printable Dynamic Hydrogel: As Simple as it Gets!

Aitor Díaz1, Helena Herrada-Manchón2, Juliana Nunes1

  • 1CIDETEC, Basque Research and Technology Alliance (BRTA), Parque Científico y Tecnológico de Gipuzkoa, Miramon Pasealekua, 196, Donostia-San Sebastián, 20014, Spain.

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|July 29, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed the simplest dynamic hydrogel for 3D bioprinting. This thiol-functionalized hyaluronic acid and gold ion formulation prints without external stimuli, enabling precise 3D constructs.

Keywords:
3D printingbio-inksbiomaterialsdynamic hydrogelshyaluronic acidself-healing hydrogels

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • 3D Bioprinting

Background:

  • 3D printing is revolutionizing tissue engineering, requiring advanced biomaterials.
  • Current 3D bioprinting hydrogels often need post-printing cross-linking.
  • Dynamic hydrogels offer promise due to extrudability and self-healing but achieving desired rheology is challenging.

Purpose of the Study:

  • To present the simplest formulation of a dynamic hydrogel for 3D bioprinting.
  • To develop a printable hydrogel that does not require external stimuli for cross-linking.
  • To demonstrate the printability and construct precision of the novel hydrogel.

Main Methods:

  • Formulation of a dynamic hydrogel using thiol-functionalized hyaluronic acid and gold ions.
  • Rheological studies to assess printability and self-healing properties.
  • 3D printing of the hydrogel to create multi-layered constructs.

Main Results:

  • The developed hydrogel formulation meets printability requirements without external stimuli.
  • Rheological studies confirmed the material's suitability for extrusion and shape retention.
  • Successful 3D printing achieved precise constructs up to 10 mm high (24 layers).

Conclusions:

  • This study introduces the simplest 3D printable dynamic hydrogel to date.
  • The formulation demonstrates excellent printability and potential for tissue engineering applications.
  • This breakthrough is expected to advance the field of 3D bioprinting with cells and biological compounds.