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Elevated cardiac troponin I and short-term mortality in patients with acute type A aortic dissection

Shuai Liu1,2, Chenxi Song1,2, Xiaohui Bian1,2

  • 1Cardiometabolic Medicine Center, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

European Heart Journal. Acute Cardiovascular Care
|July 29, 2022
PubMed

Insights

Elevated cardiac troponin I (cTnI) is common in acute type A aortic dissection (ATAAD) patients and independently predicts higher 30-day mortality. This finding improves risk prediction for ATAAD outcomes.

Area of Science:

  • Cardiology
  • Thoracic Surgery
  • Biomarkers

Background:

  • Acute type A aortic dissection (ATAAD) is a life-threatening cardiovascular emergency.
  • Prognostic markers for ATAAD are crucial for timely intervention and patient management.

Purpose of the Study:

  • To investigate the association between elevated serum cardiac troponin I (cTnI) levels and 30-day mortality in patients diagnosed with ATAAD.

Main Methods:

  • A cohort of 1321 patients with computed tomography-confirmed ATAAD was retrospectively analyzed.
  • Serum cTnI levels were measured on admission, categorizing patients into troponin-positive (>0.02 ng/mL) and troponin-negative (≤0.02 ng/mL) groups.
  • Multivariate logistic regression and risk prediction model analysis were employed.

Main Results:

  • 39.5% of ATAAD patients had elevated cTnI.
  • Troponin-positive patients exhibited significantly higher 30-day mortality (44.4% vs. 19.4%, P < 0.0001).
  • Elevated cTnI emerged as an independent predictor of 30-day mortality (OR: 2.582) and enhanced prognostic model accuracy.

Conclusions:

  • Elevated cTnI is a frequent finding in ATAAD patients.
  • Increased cTnI levels are significantly associated with a higher risk of 30-day mortality in ATAAD.
  • Serum cTnI serves as a valuable independent prognostic biomarker for short-term mortality in ATAAD.
Abstract

Keywords:
Acute aortic dissectionMortalityTroponin

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