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Related Concept Videos

Schizophrenia01:17

Schizophrenia

205
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
205
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

133
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
133
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

179
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
179
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

213
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
213
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

913
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
913
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

116
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
116

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Sex/Gender differences in schizophrenia: Thinking back and thinking forward.

Mary V Seeman1

  • 1Professor Emerita, Department of Psychiatry, University of Toronto, #605 260 Heath Street West, Toronto, Ontario, Canada, M5P 3L6.

Psychiatry Research
|July 29, 2022
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Summary

This commentary explores lifelong research into sex and gender differences in schizophrenia. It offers insights into research influences and provides recommendations for future scientists in psychiatry.

Keywords:
FutureGenderPastResearchSchizophreniaSex

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Genetics

Background:

  • Schizophrenia exhibits notable sex and gender differences.
  • Understanding these differences is crucial for effective treatment.

Purpose of the Study:

  • To summarize a career's work on sex and gender in schizophrenia.
  • To reflect on research influences and guide future studies.

Main Methods:

  • This is a commentary, not an empirical study.
  • It synthesizes personal research experiences and observations.

Main Results:

  • Sex and gender significantly impact schizophrenia presentation and progression.
  • Research trajectories are influenced by personal interests and scientific context.

Conclusions:

  • Continued investigation into sex and gender differences in schizophrenia is vital.
  • Future researchers should consider diverse influences and interdisciplinary approaches.