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A drug-loaded amphiphilic polymer/poly(l-lactide) shape-memory system.

Yajun Ren1, Xiaohong Hu1, Youhua Chen1

  • 1School of Chemical Engineering, Changchun University of Technology, China.

International Journal of Biological Macromolecules
|July 29, 2022
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Summary

Biodegradable shape-memory polymers (SMPs) offer controlled drug delivery for medical devices. This study developed a novel polymer system demonstrating excellent shape recovery and tunable drug release profiles.

Keywords:
Drug releasePLLAPVADSM

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Area of Science:

  • Polymer Science
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Biodegradable shape-memory polymers (SMPs) are advanced functional materials with significant potential in medical device applications.
  • These materials are designed to achieve specific therapeutic shapes and controlled drug release profiles post-implantation.
  • Current limitations include achieving precise control over drug release kinetics and mechanical stability.

Purpose of the Study:

  • To synthesize and characterize a novel biodegradable amphiphilic polymer (PVAD) for shape-memory drug delivery.
  • To construct and evaluate a shape-memory (SM) system using PVAD and poly(l-lactide) (PLLA) for controlled drug release.
  • To investigate the influence of temperature and shape-memory cycles on drug release mechanisms and material properties.

Main Methods:

  • Synthesis of an amphiphilic polymer (PVAD) using polytetrahydrofuran (PTMG), vinyl acetate (VAc), acrylic acid (AA), and tetramethyltetravinylcyclotetrasiloxane (D4vi).
  • Fabrication of a "reservoir-matrix" drug delivery system by encapsulating a hydrophilic drug within PVAD and embedding it in a PLLA matrix.
  • Assessment of shape recovery ratio (Rr) using heat-water stimulation and evaluation of drug release kinetics under varying temperatures and after multiple SM cycles.

Main Results:

  • The developed PVAD/PLLA system achieved a shape recovery ratio (Rr) of 99% upon heat-water stimulation.
  • Drug release rate increased with rising temperature, exhibiting an initial burst release.
  • Drug release rate was further enhanced after three shape-memory cycles, indicating a mechanism responsive to mechanical stimuli.
  • The medicated PVAD/PLLA exhibited favorable mechanical properties with a yield strength of 29.8 MPa and elongation at break of 44.6%.

Conclusions:

  • The novel PVAD/PLLA shape-memory system effectively controls drug release through a "reservoir-matrix" mechanism, influenced by temperature and mechanical stimuli.
  • The material demonstrates excellent shape recovery and suitable mechanical properties for potential use in advanced drug delivery applications.
  • This research opens new avenues for developing sophisticated drug carrier matrices in Pharmaceutical Sciences.