The quest for multiscale brain modeling

Addressing the multiscale organization of the brain, which is fundamental to the dynamic repertoire of the organ, remains challenging. In principle, it should be possible to model neurons and synapses in detail and then connect them into large neuronal assemblies to explain the relationship between microscopic phenomena, large-scale brain functions, and behavior. It is more difficult to infer neuronal functions from ensemble measurements such as those currently obtained with brain activity recordings. In this article we consider theories and strategies for combining bottom-up models, generated from principles of neuronal biophysics, with top-down models based on ensemble representations of network activity and on functional principles. These integrative approaches are hoped to provide effective multiscale simulations in virtual brains and neurorobots, and pave the way to future applications in medicine and information technologies.