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The wheezy infant: A viewpoint from low-middle income countries
Helena Teresinha Mocelin1, Luiz Vicente Ribeiro Ferreira da Silva Filho2, Jose A Castro-Rodriguez3
1Department of Paediatrics, Federal University of Health Sciences of Porto Alegre (UFCSPA), Brazil; Paediatric Pulmonology Section, Hospital da Criança Santo Antônio, Porto Alegre, Brazil.
Paediatric Respiratory Reviews
|July 29, 2022
Summary
Recurrent wheezing in children under 3 is common in low- and middle-income countries (LMICs). Targeted interventions and phenotype selection may reduce the burden of this condition.
Area of Science:
- Pediatrics
- Respiratory Medicine
- Global Health
Background:
- Recurrent and severe wheezing is a significant health concern in young children.
- Low- and middle-income countries (LMICs) face a notable burden of wheezy infants compared to other regions.
Purpose of the Study:
- To review recent evidence on recurrent/severe wheezing in children under 3 in LMICs.
- To explore epidemiological, etiological, diagnostic, treatment, and prevention aspects.
- To provide a resource-conscious approach for managing wheezing in LMICs.
Main Methods:
- Non-systematic literature review, focusing on publications from the last 5 years.
- Inclusion of studies on epidemiology, etiology, diagnosis, treatment, and prevention.
- Review of differential diagnoses and prevention strategies tailored for LMICs.
Main Results:
- Epidemiological data indicate a high prevalence of wheezy infants in LMICs.
- Differential diagnosis must consider local resources; few treatments are well-studied.
- Primary prevention is challenging, but secondary (environmental) prevention may offer benefits.
Conclusions:
- Recurrent/severe wheezing in children under 3 is a prevalent issue in LMICs, contributing to significant morbidity.
- Further research is needed to address this health challenge.
- Phenotype selection for inhaled corticosteroid responsiveness may help reduce the burden.
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