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Optical barcoding using polarisation sensitive plasmonic biosensors for the detection of self-assembled monolayers
Eugeniu Balaur1,2, Catherine Sadatnajafi3,4, Brian Abbey3,4
1Department of Mathematical and Physical Sciences, School of Engineering, Computing and Mathematical Sciences, Bundoora, VIC, 3086, Australia. e.balaur@latrobe.edu.au.
Scientific Reports
|July 29, 2022
Summary
Bimodal plasmonic color filters detect dielectric changes for sensitive molecular sensing. These silver-based devices offer miniaturization and real-time monitoring of single molecules without labeling.
Area of Science:
- Plasmonics
- Nanophotonics
- Biosensing
Background:
- Periodic subwavelength apertures modify plasmon resonances to detect dielectric variations.
- Resonance peaks act as fingerprints for the local sample environment's dielectric properties.
Purpose of the Study:
- Utilize bimodal silver-based plasmonic color filters for molecular sensing.
- Explore device sensitivity to incident polarization and analyte refractive index.
- Apply the concept to real-time monitoring of self-assembled monolayer formation.
Main Methods:
- Investigated optical output versus incident polarization for various analytes.
- Quantified sensor sensitivity based on refractive index changes.
- Employed a spectrometer for real-time optical output detection.
Main Results:
- Maximized and quantified sensor sensitivity by correlating optical output with analyte refractive index.
- Successfully monitored the real-time formation of self-assembled monolayers.
- Demonstrated detection capabilities down to the single-molecule level.
Conclusions:
- Bimodal plasmonic devices offer label-free, real-time molecular sensing.
- These devices can be miniaturized and their optical output tailored for specific analytes.
- Potential for analyzing small sample volumes and maximizing dynamic range.
