Related Experiment Video
Updated: Sep 3, 2025

04:12
Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
Published on: January 19, 2024
1.0K
Update on Melasma-Part II: Treatment
Daniel P Cassiano1, Ana Cláudia C Espósito2, Carolina N da Silva2
1Departamento de Dermatologia, UNIFESP, São Paulo, SP, Brazil.
Dermatology and Therapy
|July 29, 2022
Summary
Melasma, a common skin pigment disorder, currently lacks a cure but can be managed. This review covers photoprotection, topical and oral treatments, and procedures for melasma control and prevention.
Area of Science:
- Dermatology
- Pigmentary Disorders
Background:
- Melasma is a frequent, chronic, and relapsing pigmentary disorder.
- It predominantly affects sun-exposed areas, particularly in women of childbearing age.
Purpose of the Study:
- To critically review current knowledge on melasma management.
- To explore strategies for the control and prevention of melasma.
Main Methods:
- Literature review of photoprotection, topical therapies, and oral treatments.
- Analysis of procedural interventions including peelings, laser therapy, and microneedling.
Main Results:
- Current management focuses on control and prevention due to the absence of a definitive cure.
- Established strategies include photoprotection, various topical and oral agents, and procedural interventions.
Conclusions:
- Understanding melasma pathogenesis is incomplete, highlighting the need for further research.
- Future therapeutic strategies may target pathways promoting sustained pigmentation rather than solely melanin reduction.
Related Concept Videos
Skin Cancer
4.4K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.4K
Changes in Skin Color: Clinical Perspectives
2.1K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.1K
Pigmentation
2.6K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.6K

