NEUROMETABOLIC STRATEGY OF PHARMACOTHERAPY FOR PATIENTS WITH SERONEGATIVE ARTHRITIS

The aim: The search for optimization of the strategy of neurometabolic pharmacotherapy in patients with seronegative arthritis is relevant: ankylosing spondylitis and psoriatic arthritis, taking into account the nature of the psychological response to the disease.

Materials and methods: The study included (1st observation group) 36 patients with AS (17 men and 19 women) aged 25 to 65 years, average duration of AS - 10.9 ± 0.63 years. Degree of pathological process activity was determined taking into account the Bath AS disease activity index (BASDAI) - in accordance with EULAR criteria. The second group included 32 patients with a diagnosis of PSA (19 men and 13 women) aged 25 to 65 years according to the CASPAR 2006 criteria, the average duration of psoriasis is 13.9 ± 1.9 years, PSA - 10.6 ± 0.58 years. To study the psycho-emotional state, the Spielberger anxiety self-assessment scale was used. To identify the symptoms of depression was used Hamilton Depression Scale (HDS).

Results: In the study groups noted a high frequency of inadequate socio-psychological response to the disease. In groups of patients with seronegative arthritis, multidirectional maladaptive reactions were noted: in ankylosing spondylitis, a hypochondriac type of response is characteristic, and in psoriatic arthritis, anxiety disorders with different response options. At the end of the observation period in both groups there was an improvement in almost all studied indicators of clinical and laboratory activity.

Conclusions: There was a significant improvement in the psycho-emotional status of patients, which makes it possible to improve the quality of life of patients and contribute to the optimization of treatment and rehabilitation measures.