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Kidney Complications and Hospitalization in Patients With Chronic Hypoparathyroidism: A Cohort Study in Sweden

Oskar Swartling1, Marie Evans2,3, Tim Spelman4

  • 1Department of Medicine, Clinical Epidemiology Division, Karolinska Institutet, Stockholm 171 77, Sweden.

The Journal of Clinical Endocrinology and Metabolism
|July 30, 2022
PubMed

Insights

Patients with chronic hypoparathyroidism (hypoPT) face higher risks of chronic kidney disease (CKD), urolithiasis, and hospitalization. This highlights the need for careful monitoring and management of kidney health in hypoPT patients.

Area of Science:

  • Endocrinology
  • Nephrology
  • Public Health

Background:

  • Chronic hypoparathyroidism (hypoPT) is often managed with activated vitamin D and calcium, which may increase kidney complication risks.
  • Understanding the long-term renal outcomes in patients with hypoPT is crucial for effective patient management.

Purpose of the Study:

  • To investigate the risk of developing chronic kidney disease (CKD) and urolithiasis in patients with chronic hypoPT.
  • To assess the incidence rates of hospitalization in individuals with chronic hypoPT.

Main Methods:

  • A population-based cohort study in Sweden utilized national registries from 1997 to 2018.
  • 1562 patients with chronic hypoPT (without pre-existing CKD) were matched with 15,620 controls.
  • Time to CKD and urolithiasis diagnosis, and hospitalization rates were determined.

Main Results:

  • Patients with chronic hypoPT showed a significantly higher risk of developing CKD (HR 4.45) and urolithiasis (HR 3.55) compared to controls.
  • Incidence rates for all-cause hospitalization (49.59 per 100 person-years) and CKD (3.46 per 100 person-years) were substantially higher in the hypoPT group.
  • Men with hypoPT appeared to have a greater risk of CKD than women.

Conclusions:

  • Chronic hypoparathyroidism is associated with an increased risk of CKD, urolithiasis, and hospitalization.
  • These findings underscore the importance of vigilant renal monitoring for patients with chronic hypoPT, particularly those on activated vitamin D and calcium therapy.
Abstract

Keywords:
chronic kidney diseaseepidemiologyhypoparathyroidismurolithiasis

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