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Related Experiment Video

Updated: Sep 3, 2025

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Nanoparticle sizing by focused-beam dynamic ultrasound scattering method.

Kana Kitao1, Tomohisa Norisuye1

  • 1Department of Macromolecular Science and Engineering, Graduate School of Science & Technology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.

Ultrasonics
|July 30, 2022
PubMed
Summary

This study introduces a novel method for precisely measuring nanoparticle size using megahertz ultrasound pulses. The technique overcomes acoustic flow limitations, enabling high-speed, high-precision analysis of submicron particles.

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Area of Science:

  • Nanotechnology
  • Acoustics
  • Materials Science

Background:

  • Nanoparticle characterization is crucial for various applications.
  • Ultrasound scattering offers a potential method for nanoparticle sizing.
  • Limitations include low scattering intensity and acoustic flow interference.

Purpose of the Study:

  • To develop a high-speed, high-precision nanoparticle measurement technique using ultrasound.
  • To overcome the challenge of acoustic flow generated by high-intensity ultrasound.
  • To enable accurate nanoparticle size determination and discrimination in mixtures.

Main Methods:

  • Utilized focused megahertz ultrasound transducers for high energy delivery.
  • Employed high-frequency sensors to enhance scattering signal detection.
Keywords:
Particle sizingScatteringUltrasound

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  • Implemented short pulse repetition times and confined sample geometry to suppress acoustic flow.
  • Analyzed time correlation functions of ultrasound pulses for diffusion coefficient calculation.

    • Main Results:

    • Successfully measured the hydrodynamic radius of 15 nm silica nanoparticles.
    • Achieved particle size discrimination in mixed suspensions.
    • Demonstrated direct tracking of nanoparticle diffusive motion without perturbing dynamics.
    • Validated the technique for submicron particle analysis beyond visible light diffraction limits.

    Conclusions:

    • The developed method enables high-speed, high-precision nanoparticle sizing via megahertz ultrasound.
    • Suppression of acoustic flow is critical for accurate measurements.
    • This technique offers advantages for analyzing nanoparticles in the submicron range.