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Updated: Sep 3, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
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The SARS-CoV-2 targeted human RNA binding proteins network biology to investigate COVID-19 associated manifestations

Kartikay Prasad1, Pratibha Gour2, Saurabh Raghuvanshi2

  • 1Amity Institute of Neuropsychology & Neurosciences, Amity University, Noida, UP 201303, India.

International Journal of Biological Macromolecules
|July 30, 2022
PubMed

Insights

This study reveals shared RNA binding proteins (RBPs) linking COVID-19, cancer, and neurological disorders. Targeting these RBPs through drug repurposing may offer new therapeutic strategies for COVID-19 comorbidities.

Area of Science:

  • Biomedical research
  • Systems biology
  • Network analysis

Background:

  • The COVID-19 pandemic presents significant social and economic challenges.
  • Understanding COVID-19 comorbidities is crucial for effective treatment.
  • Drug repurposing offers a rapid therapeutic development pathway.

Purpose of the Study:

  • To investigate the molecular interplay between COVID-19, cancers, and neurological disorders.
  • To identify shared RNA binding proteins (RBPs) implicated in these conditions.
  • To explore therapeutic strategies for COVID-19 comorbidities.

Main Methods:

  • A network-based systems biology approach was employed.
  • Analysis focused on RNA binding proteins (RBPs) common to COVID-19, cancers, and neurological disorders.
  • Identification of microRNAs (miRNAs) targeting shared RBPs.

Main Results:

  • A network of nine RBPs was identified, connecting COVID-19 with 10 cancer types and 22 brain disorders.
  • Five antiviral miRNAs targeting these shared RBPs were highlighted.
  • The findings suggest a complex molecular basis for COVID-19 comorbidities.

Conclusions:

  • Shared RBPs play a significant role in the comorbidities associated with COVID-19.
  • Targeting these RBPs via drug repurposing presents a promising therapeutic avenue.
  • This network-based analysis enhances understanding of COVID-19's molecular underpinnings.
Keywords:
COVID-19CancerNetworkNeurodegenerationRNA binding proteinsmiRNAs

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