Related Experiment Video
Updated: Sep 3, 2025
09:36
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
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Inhaled sedation in the intensive care unit.
Matthieu Jabaudon1, Ruoyang Zhai2, Raiko Blondonnet1
1Department of Perioperative Medicine, CHU Clermont-Ferrand, Clermont-Ferrand, France; GReD, Université Clermont Auvergne, CNRS, INSERM, Clermont-Ferrand, France.
Anaesthesia, Critical Care & Pain Medicine
|July 30, 2022
Summary
Inhaled sedation using isoflurane or sevoflurane is now possible in intensive care units (ICUs). This method offers efficient, titratable sedation and potential clinical benefits for ICU patients.
Area of Science:
- Anesthesiology and Critical Care Medicine
- Pharmacology
Background:
- Inhaled sedation with halogenated agents is now feasible in intensive care units (ICUs).
- Requires specialized equipment and trained intensive care unit (ICU) teams.
- Isoflurane and sevoflurane possess ideal pharmacological properties for sedation.
Purpose of the Study:
- To summarize the pharmacological basis and practical aspects of inhaled ICU sedation.
- To review evidence supporting inhaled sedation as an alternative to intravenous sedation.
- To discuss uncertainties and future perspectives in inhaled sedation.
Main Methods:
- Review of pharmacological properties of isoflurane and sevoflurane.
- Analysis of existing literature on inhaled sedation in ICUs.
- Discussion of clinical benefits and practical considerations.
Main Results:
- Isoflurane and sevoflurane enable efficient, well-tolerated, and titratable sedation (light to deep).
- These agents may offer additional clinical benefits relevant to ICU patients.
- Inhaled sedation is presented as a viable alternative to intravenous sedation.
Conclusions:
- Inhaled sedation with halogenated agents is a practical and effective option for ICU patients.
- Further research is needed to address remaining uncertainties and explore future developments.
- This sedation strategy requires specific equipment and adequate team training.
Keywords:
acute respiratory distress syndromeinhaled sedationintensive care unitisofluranesevofluraneMore Related Videos
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