Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

1.1K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.1K
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

452
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
452
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

76
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
76
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

124
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
124
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

727
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
727
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

1.3K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenotype and Genetics of Spinocerebellar Ataxia Type 27B: Novel Movement-disorder Features, Cognitive Impairment, and Repeat Expansion Findings.

Cerebellum (London, England)·2026
Same author

Non-ICANS neurotoxicity after BCMA-directed CAR-T therapy: Clinical spectrum, outcomes, and a framework for neurology-oncology co-management.

HemaSphere·2026
Same author

The p.(Leu97Ile) variant expands the genetic landscape of NEFL-associated Charcot-Marie-tooth neuropathies.

Human molecular genetics·2026
Same author

Bridging past and future: the evolution of genetic diagnosis in FSHD and the role of emerging technologies in a globalized framework.

Neuromuscular disorders : NMD·2026
Same author

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult-Onset in a 46-Year-Old Male.

American journal of medical genetics. Part A·2026
Same author

Bispecific T cell engagers for treatment-refractory autoimmune connective tissue diseases.

Nature medicine·2026

Related Experiment Video

Updated: Sep 3, 2025

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients
09:44

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Published on: April 12, 2011

81.6K

Persistent hypokalaemia and intermittent muscle weakness.

Monika Rabenstein1, Angela Abicht2,3, Anna Brunn4

  • 1Department of Neurology, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany monika.rabenstein@uk-koeln.de.

Practical Neurology
|July 30, 2022
PubMed
Summary

This case study emphasizes investigating hypokalemia (low potassium) in patients with muscle weakness. It shows hypokalemia can cause neuromuscular symptoms, distinct from channelopathies.

Keywords:
ION TRANSPORTRENAL MEDICINE

More Related Videos

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties
08:27

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties

Published on: February 19, 2020

14.3K
Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
14:02

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

24.0K

Related Experiment Videos

Last Updated: Sep 3, 2025

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients
09:44

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Published on: April 12, 2011

81.6K
Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties
08:27

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties

Published on: February 19, 2020

14.3K
Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
14:02

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

24.0K

Area of Science:

  • Neurology
  • Endocrinology
  • Genetics

Background:

  • A 20-year-old male presented with a 9-year history of exercise-induced muscle pain and weakness.
  • He experienced severe rhabdomyolysis following cold exposure.
  • Longstanding hypokalemia was noted but not adequately managed.

Purpose of the Study:

  • To highlight the diagnostic importance of investigating hypokalemia in patients with neuromuscular symptoms.
  • To differentiate hypokalemia-induced neuromuscular issues from muscular channelopathies.

Main Methods:

  • Case report analysis.
  • Review of patient's medical history, focusing on neuromuscular symptoms and electrolyte imbalances.
  • Differential diagnosis considering channelopathies and metabolic disorders.

Main Results:

  • The patient's recurrent muscle pain and weakness were linked to hypokalemia.
  • Hypokalemia was identified as the primary cause of his neuromuscular symptoms.
  • The findings underscore the need for thorough investigation of hypokalemic patients.

Conclusions:

  • Hypokalemia can manifest as significant neuromuscular symptoms, independent of muscular channelopathies.
  • Methodical investigation of hypokalemic patients is crucial for accurate diagnosis and management.
  • This case broadens the understanding of hypokalemia's impact on neuromuscular function.