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Direct intracranial recordings in the human angular gyrus during arithmetic processing.

Pedro Pinheiro-Chagas¹, Fengyixuan Chen¹, Niki Sabetfakhri¹

¹Laboratory of Behavioral and Cognitive Neuroscience, Stanford Human Intracranial Cognitive Electrophysiology Program, Department of Neurology and Neurological Science, Stanford University, Stanford, CA, 94305, USA.

Brain Structure & Function

|July 30, 2022

Summary

This summary is machine-generated.

The angular gyrus (AG) shows minimal direct involvement in arithmetic processing, with observed activations often near its borders. Electrophysiological data suggest prior "activations" may stem from group analysis or interpretation of deactivations.

Keywords:

Intracranial electrophysiology Mathematical cognition Posterior parietal cortex

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Performing Behavioral Tasks in Subjects with Intracranial Electrodes

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Published on: October 2, 2014

Area of Science:

Neuroscience
Cognitive Neuroscience
Electrophysiology

Background:

The role of the angular gyrus (AG) in arithmetic processing is debated.
Previous neuroimaging studies suggest AG involvement, but the precise function remains unclear.

Purpose of the Study:

To investigate the electrophysiological engagement of the angular gyrus (AG) during arithmetic tasks.
To clarify the AG's role in processing digits and number words during addition and multiplication.

Main Methods:

Electrophysiological recordings from 467 sites across the AG, supramarginal gyrus (SMG), intraparietal sulcus (IPS), and superior parietal lobule (SPL) in 30 subjects.
Measurement of high-frequency-broadband (HFB) signal power as a marker of cortical activity.
Analysis of HFB changes during arithmetic tasks (addition/multiplication) using digits or number words, considering individual anatomical boundaries.

Main Results:

The AG showed the lowest proportion of activated or deactivated sites compared to other inferior parietal cortex subregions during arithmetic.
Activated AG sites were predominantly located at the borders with the IPS and SMG.
AG sites exhibited greater deactivation during faster response times and showed consistent HFB changes regardless of number format (digits/words) or operation (addition/multiplication).

Conclusions:

Prior neuroimaging findings of AG "activations" may be artifacts of group analyses or interpretation of relative deactivations.
Electrophysiological data suggest a more nuanced or indirect role for the AG in arithmetic processing than previously assumed.
This study provides electrophysiological evidence challenging the direct engagement of the AG in core arithmetic operations.