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RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially

Jana H Badrani1, Allyssa N Strohm1,2, Lee Lacasa1

  • 1Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, CA, USA.

Nature Communications
|July 30, 2022
PubMed
Summary

RNA-binding motif 3 (RBM3) suppresses lung innate lymphoid cell (ILC) responses in asthma. Loss of RBM3 enhances ILC activation and allergic lung inflammation, partly via cysteinyl leukotriene 1 receptor (CysLT1R).

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