Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cognitive Development During Adulthood

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.

Alzheimer's Disease: Treatment

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

Cofactors and Coenzymes

Cofactors and Coenzymes

Enzymes require additional components for proper function. There are two such classes of molecules: cofactors and coenzymes. Cofactors are metallic ions and coenzymes are non-protein organic molecules. Both of these types of helper molecule can be tightly bound to the enzyme or bound only when the substrate binds.

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Coenzyme Q<sub>10</sub> Deficiency and Elevated LEAK Mitochondrial Respiration as Potential Heart Failure Markers in Ebstein Anomaly.

International journal of molecular sciences·2026

Same author

Evolution of COQ-Synthome Transcripts and CoQ Levels in Mice Tissues Along Aging: Effect of Resveratrol and Exercise.

Antioxidants (Basel, Switzerland)·2025

Same author

The Role of Immersive Experience in Anxiety Reduction: Evidence from Virtual Reality Sessions.

Brain sciences·2025

Same author

Platelet Mitochondrial Function and Endogenous Coenzyme Q<sub>10</sub> Levels Could Be Used as Markers of Mitochondrial Health in Infertile Men: A Pilot Study.

International journal of molecular sciences·2025

Same author

A Systematic Review and Meta-Analysis of Asian Exercise Techniques and Various Physical Activity Interventions in Middle and Late Adulthood Patients With Knee Osteoarthritis.

Journal of aging and physical activity·2025

Same author

Prenatal and progressive coenzyme Q<sub>10</sub> administration to mitigate muscle dysfunction in mitochondrial disease.

Journal of cachexia, sarcopenia and muscle·2024

Search research articles

Related Experiment Video

Updated: Sep 3, 2025

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Coenzyme Q10 Levels Associated With Cognitive Functioning and Executive Function in Older Adults.

Cristina Fernández-Portero¹, Josué G Amián¹, Rocío de la Bella²

¹Department of Social Anthropology, Psychology and Public Health, Pablo de Olavide University, Seville, Spain.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

|July 31, 2022

Summary

Coenzyme Q10 (CoQ10) levels are linked to cognitive function in older adults. Lower CoQ10 may indicate reduced antioxidant defenses, potentially impacting brain health and executive function as we age.

Keywords:

Coenzyme Q10 Cognitive functioning Executive function Oxidative stress

More Related Videos

Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools

Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools

Published on: July 20, 2022

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Published on: September 18, 2021

Related Experiment Videos

Last Updated: Sep 3, 2025

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools

Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools

Published on: July 20, 2022

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Published on: September 18, 2021

Area of Science:

Gerontology
Neuroscience
Biochemistry

Background:

Aging brain deterioration involves inflammation and oxidative stress.
Coenzyme Q10 (CoQ10) is linked to neurological oxidative stress and cognitive impairment.
Previous studies suggest a link between neurodegenerative diseases and CoQ10 levels in older adults.

Purpose of the Study:

To analyze the association between CoQ10 levels and cognitive functioning in older adults.
To control for factors influencing aging, including physical activity and nutritional status.
To investigate the role of CoQ10 in cognitive decline.

Main Methods:

Cross-sectional study of 64 older adults (aged 65-99).
Participants recruited from community centers.
Plasma CoQ10 levels measured and analyzed against cognitive function, controlling for physical activity and nutritional status.

Main Results:

Plasma CoQ10 levels were significantly associated with cognitive functioning in older adults.
CoQ10 levels showed a significant association with executive function.
This association remained significant after controlling for physical activity and nutritional status.

Conclusions:

Reduced cognitive capacities in older adults may be related to diminished antioxidant defenses, indicated by low CoQ10 levels.
CoQ10 may play a role in maintaining cognitive health and executive function in aging populations.
Further research is warranted to explore CoQ10 supplementation for cognitive health.