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Disease reactivation after fingolimod cessation in Multiple Sclerosis patients with pregnancy desire: A retrospective

Alix Callens1, Soline Leblanc2, Emmanuelle Le Page1

  • 1Neurology Department, Service de Neurologie, CHU Pontchaillou, CRCSEP, Rennes Clinical Investigation Centre CIC-P 1414, Rennes University Hospital Rennes University INSERM, Rennes 35033, France.

Multiple Sclerosis and Related Disorders
|July 31, 2022
PubMed

Reactivation of Multiple Sclerosis (MS) activity has been described after fingolimod cessation. Because of its contra indication during pregnancy, switch towards lower efficacy treatments are frequent in MS patients with childbearing desire but expose them to a risk of disease reactivation. In this retrospective study including 44 women with MS, a significant increase of the median annualized relapse rate was found in the year following fingolimod discontinuation compared to the period before (p < 0.0001), and 57% of women experienced at least one relapse. When considering to start fingolimod, particular attention should be paid to women with a short-term pregnancy desire.

Keywords:
Fingolimod-disease reactivationMultiple SclerosisPregnancy desire

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