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Related Concept Videos

Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
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Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Related Experiment Video

Updated: Sep 3, 2025

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
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Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

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Necroptosis pathways in tumorigenesis.

Tao Zhang1, Yingnan Wang2, Hiroyuki Inuzuka1

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Seminars in Cancer Biology
|July 31, 2022
PubMed
Summary

Necroptosis, a programmed cell death pathway, is linked to cancer development and drug resistance. Targeting necroptosis offers a novel strategy to enhance tumor therapy by overcoming resistance to apoptosis.

Keywords:
InflammationNecroptosisRIPK1RIPK3Tumorigenesis

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Necroptosis is a programmed cell death pathway mediated by the RIPK1-RIPK3-MLKL signaling cascade.
  • Dysregulation of necroptosis is implicated in various human diseases, including cancer.
  • Cancer cells often evade programmed cell death, contributing to uncontrolled growth and therapeutic resistance.

Purpose of the Study:

  • To review the current understanding of the relationship between necroptosis and cancer.
  • To explore the role of necroptosis in therapeutic resistance in tumors.
  • To discuss the potential of targeting necroptosis as a cancer treatment strategy.

Main Methods:

  • Literature review of recent findings on necroptosis and cancer.
  • Analysis of the role of necroptosis in apoptosis resistance.
  • Discussion of therapeutic strategies targeting necroptosis.

Main Results:

  • Necroptosis deregulation is associated with cancer progression.
  • Cancer's evasion of programmed cell death, including apoptosis, is a key hallmark.
  • Targeting necroptosis presents a promising approach to overcome therapeutic resistance.

Conclusions:

  • Necroptosis plays a significant role in the context of cancer.
  • Understanding necroptosis is crucial for developing effective cancer therapies.
  • Targeting necroptosis is a potential strategy to combat apoptosis resistance in cancer treatment.