Related Experiment Video

Updated: Sep 3, 2025

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

10.9K

Necroptosis pathways in tumorigenesis

Tao Zhang1, Yingnan Wang2, Hiroyuki Inuzuka1

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Seminars in Cancer Biology
|July 31, 2022
PubMed

Insights

Necroptosis, a programmed cell death pathway, is linked to cancer development and drug resistance. Targeting necroptosis offers a novel strategy to enhance tumor therapy by overcoming resistance to apoptosis.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Necroptosis is a programmed cell death pathway mediated by the RIPK1-RIPK3-MLKL signaling cascade.
  • Dysregulation of necroptosis is implicated in various human diseases, including cancer.
  • Cancer cells often evade programmed cell death, contributing to uncontrolled growth and therapeutic resistance.

Purpose of the Study:

  • To review the current understanding of the relationship between necroptosis and cancer.
  • To explore the role of necroptosis in therapeutic resistance in tumors.
  • To discuss the potential of targeting necroptosis as a cancer treatment strategy.

Main Methods:

  • Literature review of recent findings on necroptosis and cancer.
  • Analysis of the role of necroptosis in apoptosis resistance.
  • Discussion of therapeutic strategies targeting necroptosis.

Main Results:

  • Necroptosis deregulation is associated with cancer progression.
  • Cancer's evasion of programmed cell death, including apoptosis, is a key hallmark.
  • Targeting necroptosis presents a promising approach to overcome therapeutic resistance.

Conclusions:

  • Necroptosis plays a significant role in the context of cancer.
  • Understanding necroptosis is crucial for developing effective cancer therapies.
  • Targeting necroptosis is a potential strategy to combat apoptosis resistance in cancer treatment.
Keywords:
InflammationNecroptosisRIPK1RIPK3Tumorigenesis

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