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Related Experiment Video

Updated: Sep 3, 2025

Derivation of a Human Brain Organoid with Microglia Development
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Derivation of a Human Brain Organoid with Microglia Development

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Understanding Immune-Driven Brain Aging by Human Brain Organoid Microphysiological Analysis Platform.

Zheng Ao1, Sunghwa Song1, Chunhui Tian1

  • 1Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, 47405, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|July 31, 2022
PubMed
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A new platform using 3D-printed brain organoids and aged monocytes reveals that aged immune cells may drive brain aging. This discovery offers insights into neuroimmune interactions and age-related diseases.

Area of Science:

  • Neuroscience
  • Immunology
  • Aging Research

Background:

  • Immune system aging contributes to overall aging and age-related diseases.
  • Understanding neuroimmune interactions in brain aging is limited by current in vitro models.

Purpose of the Study:

  • To develop a novel platform for studying immune-driven brain aging.
  • To investigate the role of aged monocytes in brain aging using a human organoid model.

Main Methods:

  • Development of a human brain organoid microphysiological analysis platform (MAP) using 3D printing.
  • Incorporation of dynamic rocking flow to perfuse primary monocytes from young and aged donors with human cortical organoids.
  • Modeling neuroimmune interaction to assess the impact of aged monocytes on brain organoids.
Keywords:
agingbrain organoidinflammagingmicrofluidicsneuroimmune interaction

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Last Updated: Sep 3, 2025

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Main Results:

  • Aged monocytes showed increased infiltration into human cortical organoids.
  • Aged monocytes promoted the expression of aging-related markers, such as p16, within the organoids.
  • Findings suggest aged monocytes may be a driving factor in brain aging.

Conclusions:

  • The developed organoid MAP platform enables the study of dynamic neuroimmune interactions in aging.
  • This model provides a promising tool for research in aging, neuroimmunological diseases, autoimmune disorders, and cancer.
  • Aged monocytes may play a significant role in accelerating brain aging processes.