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[Persistent acantholytic dermatosis with increased light sensitivity].

A Ott

    Zeitschrift Fur Hautkrankheiten
    |March 1, 1987
    PubMed
    Summary
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    Transient Acantholytic Dermatosis (TAD) in a 72-year-old man resolved after switching from Fansidar to Resochin. UVB sensitivity normalized, suggesting a drug-induced photosensitivity reaction.

    Area of Science:

    • Dermatology
    • Photodermatology
    • Histopathology

    Context:

    • A 72-year-old male patient presented with a 6-year history of transient acantholytic dermatosis (TAD).
    • The patient's condition exhibited a histologic pattern similar to Darier's disease.
    • The onset of TAD coincided with intensive sun exposure.

    Purpose:

    • To investigate the potential link between medication, sunlight exposure, and transient acantholytic dermatosis.
    • To evaluate the role of Fansidar and Resochin in the patient's dermatologic condition.
    • To assess the patient's photosensitivity to ultraviolet B (UVB) radiation.

    Summary:

    • The patient's TAD persisted for 6 years, exacerbated by sun exposure.
    • The patient was taking Fansidar, an antimalarial drug, during the period of persistent skin condition.

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  • A marked increase in UVB sensitivity was noted.
  • Discontinuation of Fansidar and replacement with Resochin led to skin clearing.
  • UVB sensitivity returned to normal levels after one year.

    • Impact:

    • This case highlights a potential drug-induced photosensitivity reaction mimicking Darier's disease.
    • It suggests that antimalarial drugs like Fansidar can trigger or exacerbate dermatologic conditions in susceptible individuals.
    • The findings underscore the importance of considering medication history and photosensitivity in the differential diagnosis of dermatoses.