Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

37.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
37.3K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.1K
Transduction01:16

Transduction

89
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
89
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

117
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
117
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

87
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
87
Protein Networks02:26

Protein Networks

4.1K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Delphi Consensus on Optimising the Care Pathway for Adult Patients With Acute Myeloid Leukaemia (AML): Strategies to Enhance Transplant Accessibility and Feasibility in the United Kingdom.

EJHaem·2026
Same author

Transcriptional landscapes of dengue patients reveal associations between HERV activity and disease severity.

NAR molecular medicine·2026
Same author

CPX‑351 vs. FLAG‑ida in patients with high-risk AML/MDS and MDS-related gene mutations: a subgroup analysis of the UK NCRI AML19 trial.

Leukemia & lymphoma·2026
Same author

Combining Quizartinib with intensive chemotherapy in older patients with newly diagnosed AML: results of the UK NCRI AML18 Trial.

Blood·2026
Same author

The therapeutic potential of N-acetylcysteine across multiple organ systems: a narrative review.

La Clinica terapeutica·2026
Same author

Intracellular microbial shifts during COVID-19 infection and longitudinal recovery revealed by single-cell RNA sequencing.

iScience·2026

Related Experiment Video

Updated: Sep 3, 2025

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

4.4K

Integrative genomics important to understand host-pathogen interactions.

Priyanka Mehta, Aparna Swaminathan, Aanchal Yadav

    Briefings in Functional Genomics
    |July 31, 2022
    PubMed
    Summary

    Understanding infectious disease progression requires analyzing host-pathogen interactions. New genomic methods, like Holo-transcriptome sequencing, offer a holistic view of these complex relationships to improve clinical outcomes.

    Keywords:
    RNA-seqgenomic surveillancehost–pathogen interactioninfectious diseaseintegrative genomics

    More Related Videos

    A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
    13:56

    A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

    Published on: July 18, 2013

    11.3K
    Author Spotlight: Advanced Enteroid Model for Studying Host-Pathogen Interactions
    07:56

    Author Spotlight: Advanced Enteroid Model for Studying Host-Pathogen Interactions

    Published on: April 5, 2024

    2.0K

    Related Experiment Videos

    Last Updated: Sep 3, 2025

    High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
    14:58

    High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

    Published on: March 5, 2022

    4.4K
    A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
    13:56

    A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

    Published on: July 18, 2013

    11.3K
    Author Spotlight: Advanced Enteroid Model for Studying Host-Pathogen Interactions
    07:56

    Author Spotlight: Advanced Enteroid Model for Studying Host-Pathogen Interactions

    Published on: April 5, 2024

    2.0K

    Area of Science:

    • Microbiology
    • Genomics
    • Immunology

    Background:

    • Infectious diseases cause significant global morbidity and mortality.
    • Pathogen mutation and host-pathogen interactions complicate disease progression and clinical outcomes.
    • Understanding symptom variability and protection factors is crucial for effective treatment and vaccination.

    Purpose of the Study:

    • To explore advanced genomic methodologies for investigating host-pathogen interactions.
    • To provide a holistic perspective on analyzing complex biological data for disease research.
    • To connect seemingly independent functional domains influencing disease severity.

    Main Methods:

    • Utilizing high-throughput tools like multi-omics profiling and next-generation sequencing.
    • Applying integrative genomics, including RNA sequencing, to study host-pathogen interactions.
    • Proposing Holo-transcriptome-based techniques to analyze functional microbiomes.

    Main Results:

    • Genomic data can be harnessed to investigate multiple interconnected functional domains of host-pathogen interaction.
    • Advanced methods allow for the investigation of genetic drivers behind heterogeneous disease presentations.
    • Holo-transcriptome techniques can elucidate functional microbiomes.

    Conclusions:

    • Integrative genomics and Holo-transcriptome approaches offer a comprehensive strategy for studying infectious diseases.
    • These methods can unravel the complexities of host-pathogen interactions influencing disease severity and clinical outcomes.
    • A holistic perspective on investigative methodologies is essential for advancing infectious disease research.