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Related Experiment Video

Updated: Sep 2, 2025

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
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[Vaccination prophylaxis for recurrent invasive meningococcal diseases].

Andreas Müller1,

  • 1Kommission für Infektionskrankheiten und Impffragen, Deutsche Akademie für Kinder- und Jugendmedizin e. V. (DAKJ), Chausseestr. 128/129, 10115 Berlin, Deutschland.

Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
|August 1, 2022
PubMed
Summary

Recurrent invasive meningococcal disease risk is high after infection, especially with complement defects. Vaccination with 4CMenB and/or MenACWY is recommended post-infection, without prior complement screening.

Keywords:
Immunization protectionInvasive meningococcal diseaseMeningococci group A, B, C, W, YRecurrent invasive meningococcal infectionVaccination

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Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Vaccinology

Context:

  • Invasive meningococcal disease (IMD) carries significant morbidity and mortality.
  • Recurrent infections, including with the same serotype, are a risk, particularly in individuals with complement deficiencies.
  • Current vaccination guidelines require specific approaches for at-risk populations.

Purpose:

  • To outline a recommended approach for preventing recurrent invasive meningococcal infections in children and adolescents.
  • To provide guidance on timely vaccination strategies following an IMD episode.
  • To clarify the necessity of pre-vaccination screening for complement deficiencies.

Summary:

  • The Committee for Infectious Diseases and Vaccinations recommends immediate vaccination post-IMD for unvaccinated children and adolescents.
  • Vaccination should include 4-valent meningococcal B (4CMenB) and/or serogroups A, C, W, and Y (MenACWY) vaccines.
  • Screening for complement deficiencies before vaccination is not deemed necessary.

Impact:

  • Enhances prevention strategies for invasive meningococcal disease.
  • Reduces the risk of severe outcomes associated with recurrent meningococcal infections.
  • Simplifies vaccination decision-making for healthcare professionals and patients.