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Sphingolipids and DHA Improve Cognitive Deficits in Aged Beagle Dogs.

Joseph A Araujo1, Sergi Segarra2, Jessica Mendes1

  • 1InterVivo Solutions Inc., Fergus, ON, Canada.

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|August 1, 2022
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Summary
This summary is machine-generated.

A novel lipid extract containing sphingolipids and DHA improved cognitive function in aged dogs with Canine Cognitive Dysfunction Syndrome (CDS). Supplementation attenuated working memory decline and enhanced spatial recognition and executive function.

Keywords:
agingcaninecognitioncognitive dysfunction syndromeexecutive functionneurodegeneration

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Area of Science:

  • Veterinary Neurology
  • Gerontology
  • Neuroscience

Background:

  • Canine Cognitive Dysfunction Syndrome (CDS) affects senior dogs, characterized by behavioral signs linked to brain aging.
  • Aged Beagle dogs serve as a natural model for studying CDS and age-related cognitive decline.
  • Objective characterization of CDS involves validated neuropsychological test batteries.

Purpose of the Study:

  • To evaluate the effectiveness of a novel lipid extract (Biosfeen® with DHA) in attenuating cognitive deficits in aged Beagles.
  • To assess the impact of supplementation on cognitive function and brain metabolism.

Main Methods:

  • A 6-month randomized controlled trial involving two groups of aged Beagles (n=12 each).
  • Daily oral administration of either the lipid extract supplement or a placebo.
  • Cognitive function assessed using neuropsychological tests (DNMP, selective attention, discrimination learning, spatial tasks) and brain metabolism via magnetic resonance spectroscopy (MRS).

Main Results:

  • Supplemented dogs showed no decline in working memory (DNMP task) compared to placebo-treated dogs (p=0.02).
  • Significant improvements were observed in spatial discrimination and reversal learning in the supplemented group (p=0.01).
  • Magnetic resonance spectroscopy revealed increased frontal lobe glutamate and glutamine in supplemented dogs (p=0.048), potentially linked to cognitive benefits.

Conclusions:

  • The novel lipid extract may be beneficial in counteracting age-dependent cognitive deficits in dogs.
  • Results support further investigation into this supplement for treating Canine Cognitive Dysfunction Syndrome.
  • Findings may have implications for human cognitive health due to parallels in aging between dogs and humans.