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Fabrication of a PVA-Based Hydrogel Microneedle Patch.

Na Gyeong Oh1, Se Young Hwang1, Yang Ho Na1

  • 1Department of Advanced Materials, Hannam University, Daejeon 34054, Republic of Korea.

ACS Omega
|August 1, 2022
PubMed
Summary

This study developed adjustable hydrogel microneedle (MN) patches from poly(vinyl alcohol) (PVA) with tunable dissolution. The PVA MN patches demonstrated 100% skin penetration and excellent biocompatibility, showing promise for transdermal drug delivery.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Hydrogel microneedle (MN) patches offer a promising alternative for transdermal drug delivery.
  • Controlling the dissolution characteristics of poly(vinyl alcohol) (PVA) is crucial for tunable MN patch performance.
  • Existing MN technologies require optimization for enhanced skin penetration and biocompatibility.

Purpose of the Study:

  • To develop and characterize hydrogel microneedle (MN) patches using poly(vinyl alcohol) (PVA) with adjustable disassembly times.
  • To evaluate the physical properties, skin penetration capability, and biocompatibility of the fabricated PVA MN patches.
  • To investigate the effect of saponification degree on the degradation and performance of PVA-based MN patches.

Main Methods:

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  • Poly(vinyl alcohol) (PVA) was blended and processed into hydrogel microneedle (MN) patches using a molding technique.
  • The degree of saponification was varied to control the dissolution characteristics and disassembly time of the MN patches.
  • Morphological stability, needle formation, skin penetration ratio (using gelatin sheets), degradation behavior, and cytotoxicity were assessed.

    • Main Results:

    • The PVA MN patches exhibited morphological stability and excellent needle formation.
    • A 100% penetration ratio was achieved, indicating sufficient physical properties for skin penetration.
    • Degradation was observed in PVA patches with higher saponification ratios (PVA8, PVA9, PVA10), while PVA6 and PVA7 showed no degradation.
    • Cytotoxicity tests confirmed cell viability of 80% or more, indicating non-toxic properties suitable for human use.

    Conclusions:

    • Hydrogel microneedle (MN) patches fabricated from poly(vinyl alcohol) (PVA) with controlled saponification offer adjustable disassembly times and excellent skin penetration.
    • The PVA MN patches demonstrate good morphological stability and biocompatibility, comparable to existing products.
    • Saponification degree is a critical factor in tuning the degradation profile and performance of PVA-based MN patches for transdermal applications.