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Updated: Sep 2, 2025
07:18
Investigating Intestinal Barrier Breakdown in Living Organoids
Published on: March 26, 2020
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How do intestinal probiotics restore the intestinal barrier?
Hong-Zhong Gou1,2,3, Yu-Lin Zhang1,2,3, Long-Fei Ren1,2,3
1The First Clinical Medical College, Lanzhou University, Lanzhou, China.
Frontiers in Microbiology
|August 1, 2022
Summary
Intestinal probiotics strengthen the gut barrier by enhancing cell connections and immune function. This review explores how these beneficial microbes restore intestinal barrier integrity for treating related diseases.
Area of Science:
- Gastroenterology
- Microbiology
- Immunology
Background:
- The intestinal barrier prevents harmful substances from entering the body.
- Damage to the intestinal barrier exacerbates conditions like shock, trauma, and inflammation.
- Intestinal probiotics are beneficial microorganisms crucial for host health.
Purpose of the Study:
- To provide a comprehensive overview of how intestinal probiotics restore the intestinal barrier.
- To offer new therapeutic strategies for intestinal injury-related diseases.
Main Methods:
- This is a review article, synthesizing existing research.
- The review focuses on the mechanisms by which probiotics impact the intestinal barrier.
Main Results:
- Probiotics promote intestinal epithelial cell renewal and tighten cell connections.
- They increase the production of tight junction proteins and mucins.
- Probiotics support immune system development and regulate antimicrobial peptides.
Conclusions:
- Intestinal probiotics play a vital role in restoring intestinal barrier function.
- They offer a promising approach for managing diseases associated with intestinal barrier dysfunction.
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