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Related Concept Videos

Vitamins01:30

Vitamins

948
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
948
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.4K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.4K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

1.3K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.3K
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

3.4K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
3.4K
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

112
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
112
Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

1.3K
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
1.3K

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Related Experiment Video

Updated: Sep 2, 2025

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
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Vitamin C Intake and Ischemic Stroke.

Xiaolong Tang1, Hanguang Liu1, Yuan Xiao1

  • 1Department of Internal Neurology, Beilun District People's Hospital, Ningbo, China.

Frontiers in Nutrition
|August 1, 2022
PubMed
Summary

Vitamin C, an antioxidant, may reduce ischemic stroke risk. This review examines cellular, animal, and human studies to clarify this link for better public health strategies.

Keywords:
CVDischemic strokemicronutrientreviewvitamin C

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Area of Science:

  • Nutritional Science
  • Neurology
  • Cardiovascular Science

Background:

  • Ischemic stroke represents a significant global health burden.
  • Vitamin C is a vital micronutrient known for its antioxidant functions.
  • Existing research suggests a link between vitamin C and cardiovascular health, including stroke risk.

Approach:

  • This study employed an umbrella review methodology.
  • The review synthesized evidence from four distinct research domains: cellular mechanisms, animal experiments, clinical trials, and cohort studies.
  • The objective was to comprehensively assess the relationship between vitamin C intake and ischemic stroke risk.

Key Points:

  • Cellular studies indicate vitamin C's role in protecting against oxidative stress relevant to stroke pathophysiology.
  • Animal models demonstrate neuroprotective effects of vitamin C in stroke scenarios.
  • Clinical and epidemiological data suggest an association between higher vitamin C intake and reduced ischemic stroke incidence.

Conclusions:

  • The collective evidence supports a protective role for vitamin C against ischemic stroke.
  • Further research may elucidate optimal intake levels and specific mechanisms for stroke prevention.
  • Integrating vitamin C into public health initiatives could be a viable strategy for mitigating stroke risk.