Plant Bioactives in the Treatment of Inflammation of Skeletal Muscles: A Molecular Perspective

Area of Science:

• Muscle physiology and pathology
• Inflammation research
• Phytochemistry and pharmacology

Background:

• Skeletal muscle mass is regulated by protein synthesis and the myogenic program, with degeneration linked to intracellular pathway changes.
• Muscle wasting (sarcopenia) is associated with chronic inflammation, seen in diseases like inflammatory myopathies and COPD.
• Medicinal plants offer potential anti-inflammatory compounds, but research into their use for skeletal muscle conditions is challenging.

Purpose of the Study:

• To review phytoconstituents used in treating inflammatory responses in skeletal muscles.
• To provide molecular insights into the mechanisms of these plant-derived compounds.
• To bridge the gap in understanding plant-based therapies for muscle wasting.

Main Methods:

• Literature review of scientific studies on medicinal plants and skeletal muscle inflammation.
• Analysis of research on phytoconstituents and their anti-inflammatory properties.
• Exploration of molecular pathways involved in muscle degeneration and plant-mediated intervention.

Main Results:

• Identification of various plant-derived compounds with potential anti-inflammatory effects relevant to skeletal muscle.
• Elucidation of molecular mechanisms through which phytoconstituents may modulate inflammatory pathways.
• Highlighting the complex interplay between inflammation, muscle wasting, and potential phytotherapeutic interventions.

Conclusions:

• Phytoconstituents represent a promising avenue for managing skeletal muscle inflammation and sarcopenia.
• Further research is needed to fully understand and harness the therapeutic potential of medicinal plants for muscle health.
• Targeting inflammatory pathways with plant-derived compounds could offer novel strategies for treating muscle wasting diseases.