Related Experiment Video

Updated: Sep 2, 2025

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
03:47

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography

Published on: November 1, 2024

272

Helicobacter pylori Infection Maybe a Risk Factor for Cardiac Syndrome X

Dong-Hong Zhang1, Chen Yuan2, Bei-Bei Wang3

  • 1Department of Infection Disease, Shanghai Fifth People's Hospital, Shanghai, China.

Frontiers in Cardiovascular Medicine
|August 1, 2022
PubMed

Insights

Helicobacter pylori (H. pylori) infection is linked to a higher risk of Cardiac Syndrome X (CSX). This association is more pronounced in middle-aged individuals and in developing countries.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Cardiac Syndrome X (CSX) presents as angina pectoris despite normal coronary angiography.
  • Chronic inflammation from Helicobacter pylori (H. pylori) infection is a potential contributor to CSX pathogenesis.

Approach:

  • A meta-analysis was performed, systematically searching major scientific databases up to October 2021.
  • Ten case-control studies comprising 703 CSX patients and 731 controls were analyzed using R software.

Key Points:

  • H. pylori infection was significantly associated with an increased risk of CSX (OR: 8.29).
  • The association was stronger in middle-aged individuals (40-50 years, OR: 11.27) and those over 50 (OR: 7.18).
  • A notable link was observed in developing countries like Iran (OR: 12.99) and China (OR: 5.14), but not in Italy.

Conclusions:

  • H. pylori infection may be associated with an increased risk of CSX.
  • The pathogenicity appears stronger in middle-aged populations and certain developing nations.
  • Further research is required to determine if H. pylori eradication can reduce CSX incidence, particularly in these demographics.
Abstract

Keywords:
Cardiac syndrome XHelicobacter pylori infectioncytotoxin-associated gene Ameta-analysissystematic review

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