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In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice
08:40

In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice

Published on: November 22, 2017

17.7K

Mitophagy and oral cancers

Ripon Md Chowdhury1

  • 1Department of Oral and Maxillofacial Pathology, Hi Tech Dental College and Hospital, Bhubaneswar, Odisha, India.

National Journal of Maxillofacial Surgery
|August 1, 2022
PubMed

Insights

Mitophagy removes damaged mitochondria, crucial for cell survival during stress. Dysregulation impacts cancer development and offers potential therapeutic targets for cancer cell death.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Cancer Research

Background:

  • Mitophagy is a selective autophagic process for degrading damaged mitochondria.
  • It maintains mitochondrial pool integrity and cellular homeostasis.
  • Mitophagy, tumorogenesis, and cell death are interconnected processes influenced by cellular stress.

Purpose of the Study:

  • To review the mechanisms of mitophagy.
  • To explore the role of mitophagy in tumorogenesis and cell death.
  • To highlight the therapeutic potential of mitophagy in cancer, particularly oral cancers.

Main Methods:

  • Literature review of mitophagy mechanisms.
  • Analysis of the interplay between mitophagy, oncogenic stress, and cell death pathways.
  • Examination of mitophagy's role in oral cancer development and treatment.

Main Results:

  • Mitophagy regulates mitochondrial mass and reactive oxygen species production.
  • Impaired mitophagy can either promote or inhibit tumorogenesis.
  • Mitophagy's role is critical in determining cell fate under stress and oncogenic conditions.

Conclusions:

  • Mitophagy is a key regulator of cellular adaptation to stress.
  • The relationship between mitophagy and cancer offers avenues for targeted cancer therapies.
  • Understanding mitophagy mechanisms is vital for developing novel strategies to eliminate cancer cells, especially in oral cancers.
Keywords:
Autophagycell deathmitophagyoral cancerstreatmenttumorogenesis

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