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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
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Current Progress in Cancer Treatment Using Nanomaterials.

Ruirui Zhu1, Fangyuan Zhang2, Yudong Peng1

  • 1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Oncology
|August 1, 2022
PubMed
Summary

Nanomaterials offer promising cancer treatment by overcoming chemotherapy limitations like drug resistance and low specificity. Further research into targeted drug delivery using nanocarriers is crucial for clinical translation.

Keywords:
bioavailabilitycancer treatmentchemotherapydrug deliverynanodrugnanomaterialtumor microenvironment

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Area of Science:

  • Oncology
  • Materials Science
  • Nanotechnology

Background:

  • Current chemotherapy faces limitations including cytotoxicity, multi-drug resistance, and lack of specificity.
  • Nanomaterials, sized 1-100 nm, possess unique optical, magnetic, and electrical properties beneficial for cancer therapy.
  • Existing nanodrugs face challenges in clinical translation despite extensive research.

Purpose of the Study:

  • To review novel nanomaterials for cancer treatment.
  • To analyze barriers hindering the clinical translation of nanodrugs.
  • To highlight the effective application of nanomaterials in cancer therapy.

Main Methods:

  • Literature review of recent studies on nanomaterials in cancer treatment.
  • Analysis of challenges in nanodrug development and clinical application.
  • Summary of current and emerging nanomaterial applications in oncology.

Main Results:

  • Nanomaterials can enhance drug capacity, bioavailability, and specificity while reducing cytotoxicity.
  • Key challenges include overcoming cytotoxicity, understanding enhanced permeability and retention (EPR) effects, and the protein corona.
  • Numerous nanomaterials show potential, but few have reached clinical approval.

Conclusions:

  • Targeted drug delivery systems using nanocarriers are essential for advancing nanomedicine in cancer treatment.
  • Addressing current barriers is critical for the successful translation of nanomaterials into clinical practice.
  • Continued research and development are needed to fully realize the potential of nanomaterials in combating cancer.