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Atrial Flow Regulator for Postcapillary Pulmonary Hypertension: First-in-Human Transcatheter AFR Device Implantations
Georg Hansmann1,2, Anna Sabiniewicz3, Robert Sabiniewicz3
1Department of Pediatric Cardiology and Critical Care, Hannover Medical School, Hannover, Germany.
JACC. Case Reports
|August 1, 2022
Abstract:
Restrictive cardiomyopathy (RCM) has a poor prognosis and limited treatment options apart from heart transplantation (HTx). We report on the first-in-human interventional atrial flow regulator (AFR) implantations in 3 children with RCM, leading to marked clinical and hemodynamic improvement. We propose the AFR as bridge to HTx or destination therapy in RCM. (Level of Difficulty: Advanced.).
Keywords:
AFR, atrial flow regulatorHF, heart failureHFpEF, heart failure with preserved ejection fractionHTx, heart transplantationLA, left atriumLAP, left atrial pressureLV, left ventricleLVEDP, left ventricular end-diastolic pressureMR, magnetic resonanceNYHA, New York Heart AssociationPAWP, pulmonary artery wedge pressurePH, pulmonary hypertensionPVR, pulmonary vascular resistanceRCM, restrictive cardiomyopathyatrial flow regulator deviceheart failureleft atrial hypertensionpulmonary hypertensionpulmonary vascular diseaserestrictive cardiomyopathytranscatheter intervention
