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Clinical Correlates and Outcomes of Methamphetamine-Associated Cardiovascular Diseases in Hospitalized Patients in

Lara Curran1, Gregory Nah1, Gregory M Marcus1

  • 1Department of Medicine Division of Cardiology, University of California San Francisco San Francisco CA.

Journal of the American Heart Association
|August 1, 2022
PubMed

Insights

Methamphetamine use significantly increases cardiovascular disease (CVD) risk, comparable to alcohol and cocaine. Key risk factors among users include chronic kidney disease, hypertension, and mental health disorders.

Area of Science:

  • Cardiology
  • Public Health
  • Addiction Medicine

Background:

  • Methamphetamine misuse affects millions globally, with known links to cardiovascular disease (CVD).
  • Risk factors for CVD among methamphetamine users remain understudied.
  • Understanding these risks is crucial for targeted prevention and treatment strategies.

Purpose of the Study:

  • To investigate the association between methamphetamine use and the development of CVD.
  • To identify specific risk factors for CVD in methamphetamine users.
  • To compare the CVD risk associated with methamphetamine use to that of other substance use disorders.

Main Methods:

  • Analysis of hospitalized patients from the Healthcare Cost and Utilization Project database (2005-2011).
  • Inclusion of over 20 million individuals, with a focus on 66,199 methamphetamine users.
  • Statistical analysis to determine hazard ratios (HR) for CVD events, including heart failure, pulmonary hypertension, stroke, and myocardial infarction.

Main Results:

  • Methamphetamine use was associated with increased risk of heart failure (HR 1.53) and pulmonary hypertension (HR 1.42).
  • Male sex, chronic kidney disease (HR 2.38), and hypertension (HR 2.26) were significant risk factors for CVD among users.
  • Methamphetamine use showed a 32% increase in CVD risk, similar to alcohol (28%) and cocaine (47%).

Conclusions:

  • Methamphetamine use poses a substantial risk for cardiovascular disease, on par with alcohol and cocaine abuse.
  • Individuals with co-occurring chronic kidney disease, hypertension, and mental health disorders are particularly vulnerable.
  • Clinical interventions should prioritize these high-risk groups for CVD prevention and management.

Keywords:
MINOCAcongestive heart failuremethamphetaminemyocardial infarctionmyocardial infarction without coronary artery obstructionpulmonary hypertensionstroke

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