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Genes vs environment in inflammatory bowel disease: an update
Valeria Dipasquale1, Claudio Romano1
1Pediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood 'G. Barresi,' University of Messina, Messina, Italy.
Expert Review of Clinical Immunology
|August 1, 2022
Summary
Genetic and environmental factors interact to influence inflammatory bowel diseases (IBD). Understanding these gene-environment interactions is key for predicting disease progression and personalizing patient treatment for IBD.
Area of Science:
- Gastroenterology
- Immunology
- Genetics
Background:
- Inflammatory bowel diseases (IBD) result from complex interactions between genetic predisposition and environmental exposures.
- Environmental factors influence IBD susceptibility, while host genetics modulate disease phenotype and progression.
Purpose of the Study:
- To provide an updated review of the interplay between genetic and environmental factors in IBD pathogenesis.
- To discuss key environmental influences including lifestyle, medications, diet, and the microbiome.
- To highlight the significance of monogenic very early onset IBD (VEO-IBD).
Main Methods:
- Comprehensive literature review on gene-environment interactions in IBD.
- Categorization of environmental factors into lifestyle, drugs, diet, and microbes.
- Inclusion of recent findings on VEO-IBD.
Main Results:
- Environmental exposures significantly impact IBD susceptibility.
- Genetic background modulates the effects of environmental factors on IBD course and phenotype.
- Updated information on various genetic and environmental contributors to IBD.
Conclusions:
- Enhanced understanding of gene-environment interactions is crucial for predicting IBD outcomes.
- Future insights will enable personalized medicine approaches for IBD management, including therapy response and adverse event prediction.
Keywords:
Environmentgeneinflammatory bowel diseaserisk factorvery early onset inflammatory bowel diseaseMore Related Videos
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