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Addressing the Relationship Between Testosterone Levels and Urethral Stricture: A Case-Control Study.

Ignacio Puche-Sanz^1,2, Almudena Sabio-Bonilla², Pedro Vila-Braña²

¹Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.

The Journal of Urology

|August 1, 2022

Summary

Low testosterone levels (hypoandrogenism) are linked to a higher risk of anterior urethral stricture. This study found a significant association between reduced testosterone and this condition.

Keywords:

case-control studies epidemiology fibrosis testosterone urethral stricture

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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

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Published on: August 14, 2019

Area of Science:

Urology
Endocrinology
Andrology

Background:

Hypoandrogenism, characterized by low testosterone levels, is increasingly recognized for its potential systemic effects.
The relationship between testosterone levels and urethral stricture, particularly anterior urethral stricture, requires further elucidation.

Purpose of the Study:

To investigate and quantify the association between testosterone levels and the occurrence of anterior urethral stricture.
To determine if hypoandrogenism is an independent risk factor for urethral stricture.

Main Methods:

A case-control study was conducted with 149 patients diagnosed with anterior urethral stricture and 67 controls.
Blood samples were analyzed for total testosterone, free testosterone, and bioavailable testosterone.
Statistical analysis, including adjusted odds ratios (ORs), was performed to assess the association, controlling for confounding factors.

Main Results:

Patients with urethral stricture had significantly lower mean total testosterone levels (394 ng/dL vs. 488 ng/dL) compared to controls.
The rate of hypoandrogenism (total testosterone < 300 ng/dL) was substantially higher in the urethral stricture group (26% vs. 7.5%).
Increased testosterone levels were associated with decreased odds of urethral stricture, while hypoandrogenism showed a strong direct relationship with urethral stricture (adjusted OR 4.01).

Conclusions:

The study demonstrates an independent association between hypoandrogenism and anterior urethral stricture.
These findings suggest that testosterone deficiency may play a role in the pathogenesis of urethral stricture.