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Author Spotlight: A Cost-Effective Genomic Workflow for Advancing Rabies Control in Resource-Limited Settings
Published on: August 18, 2023
Evolutionary analysis of rabies virus isolates from Georgia
Leila Tabatadze1, Ekaterine Gabashvili1,2, Saba Kobakhidze1,2
1Division of Risk Assessment, Scientific-Research Center of Agriculture, 6 Marshal Gelovani Ave., 0159, Tbilisi, Georgia.
Abstract:
Genetic relationships between rabies virus (RABV) isolates recovered from dogs, jackals, and cattle in Georgia and their closest relatives were investigated by comparing their nucleoprotein (N) gene sequences. Multiple isolates from dogs and cattle were found to share identical N gene sequences, indicating a risk of dog-to-cattle rabies transmission in Georgia. Exhibiting population-selective sweeps, expansion, and genetic recombination, evolutionary analysis of Georgian RABV isolates (all belonging to the cosmopolitan clade) and isolates from Russia, Turkey, and elsewhere provided further evidence for coinfections with different rabies virus strains and transborder transmission.
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