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Association of Racial Disparities With In-Hospital Outcomes in Severe Bronchopulmonary Dysplasia

Tamorah R Lewis1, Matthew J Kielt2, Valencia P Walker2

  • 1Children's Mercy Hospital, The University of Missouri-Kansas City, Kansas City.

JAMA Pediatrics
|August 1, 2022
PubMed

Insights

Infants born to Black mothers with severe bronchopulmonary dysplasia (BPD) faced higher death rates and longer hospital stays. Further research is needed to understand these racial disparities in BPD outcomes.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Health Disparities Research

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant complication in preterm infants.
  • Severe BPD is associated with considerable short-term respiratory morbidity, but outcomes vary.
  • The underlying mechanisms for outcome variability, potentially including racial disparities, are not well understood.

Purpose of the Study:

  • To investigate the association between maternal race and mortality and hospital stay duration.
  • To analyze outcomes in a multicenter cohort of infants diagnosed with severe BPD.

Main Methods:

  • A cohort study included preterm infants (born <32 weeks gestation) with severe BPD.
  • Data were collected from January 2015 to July 2021 across 8 US centers.
  • Maternal race (Black vs. White) was the primary exposure of interest.

Main Results:

  • The study included 834 infants; 67% were born to White mothers.
  • Infants born to Black mothers had a higher odds of death (aOR 2.1) compared to White mothers.
  • Black maternal race was associated with a significantly longer hospital stay (10 days longer).

Conclusions:

  • Infants born to Black mothers with severe BPD experienced increased mortality and longer hospitalizations.
  • These findings highlight potential racial disparities in severe BPD outcomes.
  • Further research is recommended to explore sociodemographic factors driving these disparities.
Abstract

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