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Studies on some biologically active dextrans.

M E Preobrazhenskaya, E L Rosenfeld, L Kandra

    Carbohydrate Research
    |October 1, 1978
    PubMed
    Summary
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    The study found that dextran branching influences infection resistance and anticomplementary activity in mice. While more branching generally increased resistance, outer chain length may be key for this effect.

    Area of Science:

    • Immunology
    • Carbohydrate Chemistry
    • Biochemistry

    Background:

    • Dextrans are polysaccharides with diverse biological activities.
    • Understanding dextran structure-activity relationships is crucial for developing immunomodulatory agents.
    • Nonspecific resistance to infection (n.s.r.i.) and anticomplementary activity are important immune responses.

    Purpose of the Study:

    • To investigate the relationship between the structure of native dextrans and their effects on nonspecific resistance to infection in mice.
    • To determine the anticomplementary activity of native dextrans.
    • To explore how dextran branching and chain length influence these biological activities.

    Main Methods:

    • Studied six native dextrans with varying structures.

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  • Assessed nonspecific resistance to infection (n.s.r.i.) in a mouse model.
  • Measured anticomplementary activity.
  • Utilized exodextranase-catalyzed hydrolysis to analyze dextran structures.

    • Main Results:

    • Dextran's n.s.r.i. activity generally increased with greater branching, but no direct correlation was found.
    • Exodextranase hydrolysis data suggest outer chain length is important for n.s.r.i. activity.
    • Highly branched dextrans exhibited anticomplementary activity, though no direct relationship between branching extent and this activity was observed.

    Conclusions:

    • Dextran structure, particularly branching and outer chain length, significantly impacts nonspecific resistance to infection in mice.
    • Branching extent is associated with anticomplementary activity, but the precise relationship requires further investigation.
    • These findings contribute to understanding dextran immunomodulation and potential therapeutic applications.