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MiCloud: A unified web platform for comprehensive microbiome data analysis.

Won Gu1, Jeongsup Moon2, Crispen Chisina1

  • 1Department of Applied Mathematics and Statistics, The State University of New York, Korea, Incheon, South Korea.

Plos One
|August 1, 2022
PubMed
Summary
This summary is machine-generated.

MiCloud is a new web platform for microbiome data analysis. It supports various study designs and traits, offering a unified protocol for ecological and microbial taxa analyses.

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Area of Science:

  • Microbiome research
  • Bioinformatics
  • Computational biology

Background:

  • Massively parallel sequencing advances enable cost-effective microbiome profiling.
  • Human microbiome research is crucial in public health and medicine.
  • Existing web platforms for microbiome analysis have limitations in study design and covariate adjustment.

Purpose of the Study:

  • Introduce MiCloud, a unified web platform for comprehensive microbiome data analysis.
  • Expand analytical capabilities beyond categorical traits and cross-sectional designs.
  • Accommodate longitudinal/family-based studies and covariate adjustments.

Main Methods:

  • MiCloud handles binary or continuous traits and cross-sectional or longitudinal/family-based study designs.
  • It analyzes ecological measures (alpha and beta diversity) and microbial taxa abundance across taxonomic levels.
  • A unified protocol streamlines data input, quality control, transformation, statistical methods, and visualization.

Main Results:

  • MiCloud provides extended utility and flexibility for microbiome data analysis.
  • The platform was illustrated using the United Kingdom twin study on gut microbiome and body mass index, adjusting for age.
  • MiCloud is accessible via a web server (http://micloud.kr) and a GitHub repository (https://github.com/wg99526/micloudgit).

Conclusions:

  • MiCloud offers a versatile and user-friendly solution for complex microbiome data analysis.
  • The platform enhances the ability to investigate microbiome associations with various traits and study designs.
  • MiCloud facilitates deeper insights into the human microbiome's role in health and disease.