Improving miRNA Disease Association Prediction Accuracy Using Integrated Similarity Information and Deep Autoencoders

MicroRNAs (miRNAs) are short endogenous non-encoding RNA molecules (22nt) that have a vital role in many biological and molecular processes inside the human body. Abnormal and dysregulated expressions of miRNAs are correlated with many complex disorders. Time-consuming wet-lab biological experiments are costly and labour-intensive. So, the situation demands feasible and efficient computational approaches for predicting promising miRNAs associated with diseases. Here a two-stage feature pruning approach based on miRNA feature similarity fusion that uses deep attention autoencoder and recursive feature elimination with cross-validation (RFECV) is proposed for predicting unknown miRNA-disease associations. In the first stage, an attention autoencoder captures highly influential features from the fused feature vector. For further pruning of features, RFECV is applied. The resultant features were given to a Random Forest classifier for association prediction. The Highest AUC of 94.41% is attained when all miRNA similarity measures are merged with disease similarities. Case studies were done on two diseases-lymphoma and leukaemia, to examine the reliability of the approach. Comparative analysis shows that the proposed approach outperforms recent methodologies for predicting miRNA-disease associations.