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Effect of Anti-allergic Therapy on Quality of Life in Children with Allergic Conjunctivitis and Their Parents
Zixin Fan1, Boyu Yang1, Limei Sun1
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China.
Purpose:
To evaluate the effect of anti-allergic therapy on quality of life (QoL) in children with allergic conjunctivitis (AC) and their parents.
Methods:
Prospective single-arm intervention study including 55 AC child-parent pairs. The endpoint was that AC was successfully controlled after anti-allergic therapies. The primary outcome was the change in QoL of children from baseline to endpoint as measured by the total Pediatric Quality of Life Inventory (PesdQL) score.
Results:
The total PedsQL scores of children and parents were improved after treatment (P < .001). QoL improved greater in children with vernal keratoconjunctivitis/atopic keratoconjunctivitis, those without other allergy outside the eye, and those with lower baseline total PedsQL score. Greater improvement of parents' QoL was associated with longer treating duration, greater improvement of children's QoL, lower baseline parents' total PedsQL score, and more severe baseline children's signs.
Conclusion:
Both pediatric AC patients' and their parents 'reduced QoL were improved after anti-allergic therapy.
Clinical Trial Registration:
Chinese Clinical Trial Registry Identifier: ChiCTR2000037866.
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