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Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

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Laetitia Travier¹, Roshani Singh¹, Daniel Sáenz Fernández²

¹Brain-Immune Communication Lab, Institut Pasteur, Université Paris Cité, Inserm U1224, F-75015, Paris, France.

Current Opinion in Neurobiology

|August 1, 2022

Summary

Aging tissues lose maintenance functions. In the brain, the blood-brain barrier, cerebrospinal fluid circulation, and microglia function decline, impacting cognitive health due to peripheral signals.

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Area of Science:

Neuroscience
Gerontology
Immunology

Background:

Tissue aging is characterized by the failure of daily maintenance mechanisms to cope with accumulated damage.
In the brain, key maintenance systems include the blood-brain barrier, cerebrospinal fluid circulation, and microglial phagocytic function.
Dysfunction of these brain maintenance systems is linked to cognitive decline and aging hallmarks.

Purpose of the Study:

To explore the role of peripheral factors in maintaining brain health during aging.
To discuss how systemic signals contribute to the decline of brain maintenance mechanisms.

Main Methods:

Review and synthesis of current literature on brain aging and peripheral influences.
Analysis of the interplay between systemic circulation and central nervous system maintenance.

Main Results:

Brain maintenance systems are sensitive to peripheral signals like cytokines and microbiome-derived molecules.
These peripheral factors influence the internal state of the aging brain.
Failure in response to peripheral signals exacerbates age-related brain dysfunction.

Conclusions:

Peripheral factors significantly contribute to brain maintenance and its age-related decline.
Understanding these systemic influences is crucial for addressing cognitive aging.
Targeting peripheral signals may offer therapeutic strategies for brain aging.