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Vitamin D deficiency after highly selective vagotomy.
Acta Medica Scandinavica
|January 1, 1987
Summary
Highly selective vagotomy may alter vitamin D metabolism, decreasing 25-hydroxyvitamin D and increasing 1,25-dihydroxyvitamin D. While bone mass remains normal, vitamin D supplementation might be needed long-term to prevent deficiency.
Area of Science:
- Endocrinology
- Gastroenterology
- Bone Metabolism
Background:
- Bone disease is an occasional complication after gastrectomy.
- The specific impact of vagotomy on calcium and vitamin D metabolism remains unclear.
Purpose of the Study:
- To investigate the effects of highly selective vagotomy on calcium and vitamin D metabolism in male patients.
- To assess bone mass and turnover markers in patients post-vagotomy.
Main Methods:
- Studied 23 male patients who underwent highly selective vagotomy for ulcer treatment.
- Measured serum concentrations of 25-hydroxyvitamin D (25OHD), 1,25-dihydroxyvitamin D (1,25(OH)2D), and parathyroid hormone.
- Assessed local and total bone mass and biochemical markers of bone turnover.
Main Results:
- Patients showed decreased 25OHD levels (p<0.05) and elevated 1,25(OH)2D levels (p<0.05).
- Immunoreactive parathyroid hormone concentrations were normal.
- Bone mass and turnover markers were comparable to age-matched controls, with no biochemical evidence of increased bone turnover.
Conclusions:
- Changes in calcium absorption post-vagotomy are likely mediated by 1,25(OH)2D.
- Despite normal bone metabolism in the short term, long-term vitamin D deficiency is a potential risk.
- Vitamin D supplementation should be considered for patients following vagotomy.