Related Experiment Video

Updated: Sep 2, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K

Relationship between PCSK9 and endothelial function in patients with acute myocardial infarction

Paolo Cimaglia1, Francesca Fortini1, Francesco Vieceli Dalla Sega1

  • 1Maria Cecilia Hospital, GVM Care and Research, via Corriera 1, 48033, Cotignola RA, Italy.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|August 1, 2022
PubMed

Insights

Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels and endothelial dysfunction, measured by apoptosis rate, are linked in patients with ST-elevation myocardial infarction. Changes in PCSK9 correlate with endothelial function variations post-myocardial infarction.

Area of Science:

  • Cardiovascular Biology
  • Endothelial Function
  • Lipid Metabolism

Background:

  • The role of PCSK9 in lipid metabolism is established, but its association with endothelial function requires further investigation.
  • Endothelial dysfunction is a critical factor in acute myocardial infarction (AMI).

Purpose of the Study:

  • To evaluate the relationship between PCSK9 and endothelial dysfunction in patients experiencing acute myocardial infarction (specifically STEMI).

Main Methods:

  • Serum samples from 74 STEMI patients were analyzed at admission and 5 days post-admission.
  • Endothelial dysfunction was assessed by measuring the apoptosis rate (AR) of endothelial cells incubated with patient serum.
  • Correlations between PCSK9 levels and AR were examined.

Main Results:

  • A significant positive correlation was observed between PCSK9 levels and AR at baseline (r=0.649) and 5-day (r=0.648).
  • PCSK9 levels significantly increased post-STEMI (p<0.001), while AR did not (p=0.491).
  • Patients with reduced PCSK9 showed a greater decrease in AR (p=0.002), and PCSK9 change was the sole predictor of AR change (p=0.001).

Conclusions:

  • Variations in endothelial function and PCSK9 are related in the initial days following acute myocardial infarction.
  • Further research is needed to validate these findings and explore their clinical implications.
Abstract

Keywords:
Endothelial functionMyocardial infarctionPCSK9

More Related Videos

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control05:41

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Published on: December 16, 2022

3.6K
A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK908:14

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

8.2K

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
30
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
68
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
50
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
42
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
24
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
21